What is the Origin of NAD plus Precursors?

The term is derived from foundational biochemistry and the study of vitamin B3 (niacin) metabolism, which is a key component of the NAD+ salvage pathway. Clinical and longevity research has focused on the precursor molecules due to their superior bioavailability and ability to efficiently bypass rate-limiting steps in the NAD+ synthesis pathway.

What is the Mechanism of NAD plus Precursors?

Upon ingestion, precursors like NMN and NR are efficiently converted into NAD+ within the cell. Elevated NAD+ levels then act as an essential cofactor for numerous enzymatic reactions, notably those involving sirtuins, which regulate gene expression and cellular stress response, and PARPs, which are crucial for DNA repair. This boost in cellular energy and repair capacity is fundamental to maintaining tissue health and metabolic vitality.

NAD plus Precursors ∞ Area

NAD plus Precursors

Meaning

A class of biomolecules, such as Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), that serve as raw materials for the biosynthesis of Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme found in all living cells. These precursors are administered clinically to boost intracellular NAD+ levels, thereby supporting essential metabolic processes, including cellular energy production, DNA repair, and the activity of sirtuin longevity proteins. Their role is pivotal in addressing age-related decline in cellular function.