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NAD plus Homeostasis

Meaning

NAD+ Homeostasis refers to the maintenance of a stable and optimal ratio of the oxidized form of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH) within the cell. NAD+ is an essential coenzyme central to energy metabolism, DNA repair, and gene expression regulation, acting as a substrate for sirtuins and PARPs. Maintaining this balance is critical for cellular resilience, metabolic flexibility, and healthy aging, all of which impact hormonal signaling.