Therapeutic strategies aimed at maintaining or increasing intracellular concentrations of Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme for cellular energy metabolism and DNA repair.
Origin
This concept originates from cellular biology and aging research, recognizing NAD+ depletion as a key factor in age-related physiological decline.
Mechanism
Support involves providing precursors like Nicotinamide Riboside or Nicotinamide Mononucleotide, which feed into the salvage pathway to maintain adequate pools for sirtuin activation and overall mitochondrial efficiency.
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