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NAD+ Mitochondrial Biogenesis

Meaning

NAD+ Mitochondrial Biogenesis describes the dual biological process involving the synthesis of new mitochondria within the cell, known as mitochondrial biogenesis, which is significantly regulated by the coenzyme Nicotinamide Adenine Dinucleotide (NAD+). NAD+ acts as a critical cofactor for sirtuin proteins, particularly SIRT1, which in turn activates the transcriptional programs necessary to produce new, functional mitochondria. This process is essential for maintaining cellular energy production, metabolic flexibility, and is a key target for longevity and anti-aging interventions in the context of hormonal health. Declining NAD+ levels are directly linked to age-related decreases in mitochondrial function.