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NAD+ Metabolome Decline

Meaning

NAD+ Metabolome Decline refers to the age-related reduction in the total cellular concentration of Nicotinamide Adenine Dinucleotide (NAD+) and its associated metabolic precursors and derivatives. NAD+ is an essential coenzyme central to energy metabolism, DNA repair, and gene expression regulation via sirtuins and PARPs. The progressive decline in NAD+ availability is considered a critical hallmark of aging, leading to mitochondrial dysfunction, impaired cellular resilience, and reduced metabolic flexibility. Clinically, restoring NAD+ levels is a key target for longevity and anti-aging interventions.