What is the Origin of NAD+ Metabolome?

The term is a compound of "NAD+," the essential coenzyme in cellular metabolism, and "metabolome," which is the total collection of small-molecule chemicals found within a biological sample. The concept is central to the fields of gerontology and metabolic health, recognizing the well-documented age-related decline in cellular NAD+ levels. Research in this area has led to the development of various longevity interventions.

What is the Mechanism of NAD+ Metabolome?

NAD+ is an indispensable cofactor for numerous redox reactions and serves as a substrate for key longevity-associated enzymes like sirtuins and PARPs, which regulate DNA repair and gene expression. The NAD+ Metabolome functions to maintain a robust NAD+/NADH ratio, which is critical for efficient oxidative phosphorylation and cellular energy production. Imbalances or depletion in this metabolome impair cellular repair processes and mitochondrial function, thereby accelerating cellular senescence and metabolic dysfunction.

NAD+ Metabolome ∞ Area

NAD+ Metabolome

Meaning

The NAD+ Metabolome is the collective set of all molecules involved in the synthesis, degradation, and functional cycling of Nicotinamide Adenine Dinucleotide (NAD+) and its related precursors and catabolites within a biological system. This metabolome includes key molecules such as nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and the enzymes that consume NAD+, like the sirtuins and PARPs. The state of this metabolome is a crucial, dynamic biomarker for cellular energy status and the rate of biological aging.