What is the Origin of NAD+ Metabolic Support?

The understanding of NAD+ dates back to the early 20th century with its discovery as a coenzyme, but its role as a critical regulator of aging pathways gained prominence in the early 2000s with research on sirtuins and PARPs (Poly-ADP-Ribose Polymerases). The term 'Metabolic Support' reflects the clinical translation of this research, emphasizing the therapeutic goal of providing the necessary precursors or modulators to sustain the NAD+ salvage and synthesis pathways in the face of age-related depletion.

What is the Mechanism of NAD+ Metabolic Support?

The primary mechanism of support involves supplementing with NAD+ precursors, such as Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN), which are efficiently converted into NAD+ within the cell. Once elevated, NAD+ acts as a required cofactor for sirtuin enzymes, which regulate gene silencing and DNA repair, and for PARPs, which are essential for repairing single-strand DNA breaks. By fueling these critical enzymatic processes, the support enhances mitochondrial respiration and overall cellular resilience, effectively boosting the cell's energy and maintenance capabilities.

NAD+ Metabolic Support

Meaning

NAD+ Metabolic Support is the clinical strategy focused on maintaining optimal intracellular levels of Nicotinamide Adenine Dinucleotide (NAD+), a crucial coenzyme involved in hundreds of essential metabolic and cellular repair processes. Declining NAD+ levels are recognized as a key driver of aging and metabolic dysfunction, impacting energy production, DNA repair, and gene expression regulation via sirtuins. Support strategies aim to replenish this vital molecule to enhance mitochondrial function, improve cellular energy output, and bolster the cell’s capacity for self-repair and stress resistance. This is a foundational intervention in metabolic and longevity medicine.