NAD+ IV Therapy is a clinical intervention involving the intravenous administration of Nicotinamide Adenine Dinucleotide (NAD+), a vital coenzyme found in all living cells, to rapidly increase its systemic availability. This therapy is employed in wellness and longevity clinics to support cellular energy metabolism, enhance DNA repair mechanisms, and potentially improve mitochondrial function, all of which decline with age. While still considered a complementary therapy, its proponents suggest it can improve cognitive function, reduce fatigue, and support recovery from chronic stress and metabolic decline.
Origin
The term is derived from the key molecule, NAD+, and the method of delivery, Intravenous (IV) Therapy. NAD+ was first discovered in 1906, and its role as a fundamental metabolic coenzyme has been understood for decades. The modern application of high-dose intravenous delivery originated in addiction medicine but has since been adopted by the anti-aging and wellness sectors to rapidly boost cellular NAD+ pools.
Mechanism
NAD+ is an essential coenzyme for numerous enzymatic reactions, acting as an electron acceptor in redox reactions, particularly within the electron transport chain for ATP generation. The mechanism of the IV therapy bypasses the gastrointestinal tract, allowing for a higher and more immediate systemic concentration of NAD+ to enter the bloodstream. Once delivered, NAD+ serves as a substrate for critical longevity enzymes, including sirtuins and PARPs, which are responsible for DNA repair and regulating gene expression related to cellular stress and survival.
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