NAD+ Boosters are a category of compounds, typically precursors like Nicotinamide Mononucleotide (NMN) or Nicotinamide Riboside (NR), designed to increase the intracellular levels of Nicotinamide Adenine Dinucleotide (NAD+). NAD+ is a vital coenzyme present in all living cells, essential for fundamental biological processes including energy metabolism, DNA repair, and the regulation of sirtuins, which are key longevity proteins. Supplementation aims to counteract the age-related decline of this critical molecule.
Origin
The concept stems from decades of research in biochemistry and cellular metabolism, which elucidated the central role of NAD+ in the tricarboxylic acid (TCA) cycle and redox reactions. The term “booster” emerged in the longevity and anti-aging fields to describe the therapeutic strategy of using specific precursor molecules to bypass metabolic bottlenecks and replenish NAD+ stores, particularly as its levels naturally decrease with age.
Mechanism
NAD+ Boosters function by providing the necessary raw materials that cells convert into NAD+ through salvage pathways. Once NAD+ levels are elevated, it acts as a crucial cofactor for enzymes like PARPs, involved in DNA repair, and sirtuins, which regulate gene silencing and metabolic health. This mechanism supports mitochondrial function, enhances cellular energy production, and helps maintain genomic integrity, all of which are critical for robust hormonal signaling.
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