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NAD+ Bioavailability

Meaning

NAD+ bioavailability refers to the fraction of exogenously administered or endogenously synthesized Nicotinamide Adenine Dinucleotide (NAD+) or its precursors that becomes available to the body’s cells to exert its functional effects. NAD+ is an essential coenzyme central to cellular energy metabolism and redox reactions, acting as a substrate for critical longevity-associated enzymes like sirtuins and PARPs. Optimizing its bioavailability is a significant focus in aging research and clinical longevity protocols.