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N-Of-1 Biomarker

Meaning

An N-Of-1 Biomarker is a physiological measurement or data point whose clinical significance is defined and interpreted exclusively within the context of a single individual, rather than against a population-derived reference range. This approach recognizes the profound bio-individuality in hormonal health, where a ‘normal’ level for one person may be suboptimal for another’s vitality and function. The N-Of-1 framework shifts the clinical focus from simply diagnosing pathology to optimizing personal biological performance and subjective well-being. This is the essence of precision medicine in endocrinology.