What is the Origin of Myokine Signaling?

The term is a compound of the Greek word 'myo' meaning muscle and 'kine' meaning movement, signifying the muscle-derived nature of these signaling molecules that are released upon contraction. The concept originated from the recognition that the systemic benefits of exercise extend far beyond muscle hypertrophy and involve cross-talk with numerous other tissues. Irisin and IL-6 are prominent examples of myokines identified in this crucial communication pathway.

What is the Mechanism of Myokine Signaling?

Upon muscle contraction, the mechanical and metabolic stress triggers the release of myokines into the interstitial space and the circulation. These myokines then bind to specific receptors on distant target cells, initiating a cascade of effects. For instance, some myokines can enhance insulin sensitivity in adipose tissue, promote the beneficial browning of white fat, or exert neuroprotective effects in the brain, collectively contributing to the anti-inflammatory and metabolic benefits associated with regular physical activity.

Myokine Signaling

Meaning

Myokine Signaling describes the endocrine and paracrine communication mediated by myokines, which are small, biologically active peptides released by skeletal muscle fibers in response to muscle contraction, particularly during exercise. These signaling molecules act as crucial messengers between muscle and other organs, including fat, liver, bone, and the brain, modulating metabolism, inflammation, and tissue repair. This mechanism fundamentally highlights the muscle as an active, powerful endocrine organ.

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