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Myokine Signaling Pathways

Meaning

Myokine Signaling Pathways describe the complex network of communication mediated by myokines, which are small, biologically active peptides released by skeletal muscle fibers, particularly in response to muscle contraction during exercise. These myokines act as autocrine, paracrine, and endocrine factors, signaling to the muscle itself, neighboring tissues, and distant organs, respectively. This signaling is a crucial component of the body’s systemic adaptation to physical activity, linking muscular effort directly to metabolic health, anti-inflammatory responses, and neurogenesis. They are key mediators of the health benefits derived from exercise.