Skip to main content

Myokine Signaling Molecules

Meaning

These are a class of small proteins, or peptides, secreted by skeletal muscle fibers in response to muscle contraction, which act as messengers to communicate with other organs, including adipose tissue, liver, bone, and the brain. Myokines are a critical component of the endocrine function of muscle, mediating the systemic health benefits of physical activity. They exert pleiotropic effects, including anti-inflammatory, metabolic-regulating, and neuroprotective actions, making them essential for inter-organ crosstalk and overall metabolic homeostasis.