What is the Origin of Myokine Signaling Cascade?

This term is derived from "myo" (muscle) and "kine" (to move), signifying muscle-derived signaling molecules. The "cascade" component refers to the sequential nature of the biochemical signals initiated by these released factors. Its scientific foundation lies in recognizing muscle as an endocrine organ.

What is the Mechanism of Myokine Signaling Cascade?

During muscle contraction, specific myokines like Irisin or IL-6 are released into circulation or the local interstitial fluid. These molecules then bind to receptors on target cells, influencing processes such as adipocyte browning, hepatic glucose output, or even neurogenesis in the brain. The cascade operates to communicate the state of muscular activity to the rest of the endocrine system, modulating systemic energy balance and inflammation.

Myokine Signaling Cascade ∞ Area

Myokine Signaling Cascade

Meaning

The Myokine Signaling Cascade describes the complex paracrine and endocrine communication network initiated by contracting skeletal muscle fibers releasing bioactive peptides known as myokines. These molecules act both locally on adjacent muscle cells and systemically on distant organs, including adipose tissue and the liver. This cascade is a fundamental link between physical activity and systemic metabolic and hormonal health regulation.