What is the Origin of Myokine Signaling Brain?

The term 'Myokine' (from Greek myo- meaning muscle and -kine meaning movement) was introduced in 2007, recognizing muscle's capacity to secrete regulatory factors. The addition of 'Signaling Brain' specifically denotes the physiological target and effect of these molecules on the central nervous system. This area of study is relatively new, arising from research into the molecular mechanisms behind exercise-induced health benefits.

What is the Mechanism of Myokine Signaling Brain?

Upon muscle contraction, myokines such as Irisin and Cathepsin B are released into the systemic circulation. These molecules can cross the blood-brain barrier or signal via peripheral receptors to influence the brain. Inside the brain, myokines modulate inflammation, promote angiogenesis, and crucially, stimulate the production of neurotrophic factors like BDNF. This signaling cascade collectively supports neuronal survival, enhances synaptic function, and facilitates neuroplasticity.

Myokine Signaling Brain ∞ Area

Myokine Signaling Brain

Meaning

The endocrine communication system wherein myokines, which are small proteins and peptides released by skeletal muscle during contraction, act as signaling molecules that exert direct and indirect effects on the central nervous system. This signaling cascade represents a vital inter-organ crosstalk, linking muscular activity and metabolic status directly to neurobiological functions like cognition, mood, and neuroprotection. It underscores the muscle’s role as an endocrine organ crucial for brain health.