What is the Meaning of Myokine Signaling?

Myokine signaling refers to the paracrine, autocrine, and endocrine communication pathway mediated by myokines, which are small peptide hormones or cytokines released by skeletal muscle fibers in response to contraction, particularly during exercise. These signaling molecules act as crucial inter-organ messengers, linking muscular activity directly to systemic metabolic health, inflammation, and the function of distant tissues like adipose tissue, liver, and brain. This pathway represents the endocrine function of muscle.

What is the Origin of Myokine Signaling?

The concept of myokine signaling was formally established in the early 2000s with the identification of IL-6 as a muscle-derived factor, challenging the traditional view of muscle solely as a locomotor and metabolic sink. The term highlights the critical role of muscle as an endocrine organ that actively participates in the body's hormonal and metabolic dialogue.

What is the Mechanism of Myokine Signaling?

The mechanism involves mechanical and metabolic stress within the contracting muscle fiber triggering the expression and release of various myokines into the circulation. These myokines then travel to target tissues: for example, Irisin is released and promotes the browning of white adipose tissue, increasing thermogenesis. Other myokines can enhance insulin sensitivity in the liver and muscle or cross the blood-brain barrier to influence cognitive function, providing a powerful physiological link between physical activity and systemic health optimization.

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