What is the Origin of Myokine Secretion Profiles?

The term is derived from 'myo-' (muscle) and '-kine' (movement or signaling), a concept formalized in the early 2000s with the discovery of Interleukin-6 (IL-6) as a muscle-derived cytokine. 'Profiles' refers to the complex, dynamic, and exercise-dependent nature of their release patterns.

What is the Mechanism of Myokine Secretion Profiles?

Myokine release is primarily triggered by muscle contraction, which causes local metabolic stress and mechanical tension, activating specific gene expression within the muscle cell. For instance, high-intensity endurance training stimulates the release of myokines like Irisin, which promotes the browning of white adipose tissue and enhances energy expenditure. Resistance training, conversely, may favor the release of myokines that promote hypertrophy, illustrating how the type of exercise dictates the specific systemic endocrine signal.

Myokine Secretion Profiles ∞ Area

Myokine Secretion Profiles

Meaning

Myokine secretion profiles represent the specific patterns and quantities of signaling peptides, known as myokines, released by skeletal muscle fibers into the circulation in response to physical activity. These myokines function as hormones, influencing communication between muscle, fat, bone, liver, and brain tissue, mediating systemic effects like anti-inflammation, insulin sensitivity, and neurogenesis. Analyzing these profiles provides insight into the systemic metabolic and endocrine benefits of specific exercise types.