What is the Origin of Myokine Regulation?

The term was coined in the early 2000s, following the discovery that contracting muscle is an endocrine organ, challenging the previous view of muscle as solely a locomotor tissue. "Myokine" combines the Greek roots myo (muscle) and kinos (movement/to move). This paradigm shift highlighted the importance of muscle mass and physical activity as a fundamental modulator of the body's hormonal and immune landscape.

What is the Mechanism of Myokine Regulation?

Myokine regulation operates by these signaling molecules binding to receptors on distant target cells, initiating specific intracellular cascades. For example, Interleukin-6, a classic myokine, can enhance glucose uptake in the liver and increase lipolysis in fat cells, contributing to improved metabolic health. The regulation of these myokines is tightly controlled by the type, intensity, and duration of muscle contraction, underscoring exercise as a powerful endocrine therapy.

Myokine Regulation ∞ Area

Myokine Regulation

Meaning

Myokine regulation refers to the control and influence exerted by myokines, which are small proteins and peptides released by skeletal muscle fibers, particularly during and after physical contraction. These molecules function as signaling hormones, mediating communication between muscle and other organs, including the brain, liver, fat tissue, and bone. Clinically, myokine release is a crucial mechanism linking physical activity to systemic health benefits, such as improved insulin sensitivity, reduced chronic inflammation, and enhanced cognitive function.