What is the Origin of Myokine Messengers?

The term combines "myo-," the Greek prefix for muscle, with "-kine," meaning movement or signal, highlighting their origin and function as mobile signaling molecules. The discovery of myokines established skeletal muscle as a major endocrine organ.

What is the Mechanism of Myokine Messengers?

Muscle contraction triggers the transcription and release of specific myokines, such as Interleukin-6 (IL-6) and Irisin, into the circulation. These messengers bind to receptors on distant target cells, modulating glucose uptake, enhancing fat oxidation, and exerting anti-inflammatory effects. This hormonal communication pathway is critical for improving insulin sensitivity and reducing the chronic, low-grade inflammation often associated with age-related endocrine decline.

Myokine Messengers ∞ Area

Myokine Messengers

Meaning

A diverse group of signaling proteins, or cytokines, secreted by skeletal muscle fibers in response to muscle contraction, which act as endocrine, paracrine, or autocrine factors. These messengers mediate the cross-talk between muscle and other organs, including the liver, adipose tissue, and brain, profoundly influencing systemic metabolism and inflammation. Myokine release is a key mechanism by which exercise exerts its beneficial, multi-systemic effects on hormonal health and longevity.