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Myokine Communication Fidelity

Meaning

Myokine Communication Fidelity refers to the accuracy and effectiveness of the paracrine and endocrine signaling mediated by myokines, which are small peptide hormones released by contracting skeletal muscle fibers. High fidelity indicates that the myokine signal—which targets distant organs like the liver, pancreas, adipose tissue, and brain—is accurately received and translated into the intended physiological response, such as improved insulin sensitivity or reduced systemic inflammation. Maintaining this fidelity is crucial for realizing the systemic health benefits of regular physical activity.