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Myogenic Differentiation

Meaning

Myogenic differentiation is the complex, irreversible biological process by which committed precursor cells, known as myoblasts, mature and subsequently fuse to form functional, multinucleated muscle fibers or myotubes. This process is absolutely fundamental to skeletal muscle development during embryogenesis and is equally crucial for effective muscle repair and regeneration in adult life. It is a highly regulated molecular cascade involving the precise activation of specific transcription factors. Hormonal signaling, particularly by anabolic androgens, is a potent positive modulator of this entire cellular pathway.