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Myofilament Calcium Sensitivity

Meaning

Myofilament calcium sensitivity is a fundamental physiological parameter that defines the responsiveness of the contractile proteins within muscle cells, known as myofilaments, to a given concentration of intracellular calcium ions. It quantifies the efficiency with which a muscle fiber generates force when activated by the calcium signal. In the context of hormonal health, thyroid hormones and androgens can modulate this sensitivity, thereby influencing cardiac contractility and skeletal muscle performance independent of the total calcium release. Optimizing this sensitivity is crucial for maintaining efficient muscle function and metabolic health.