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Myofiber Secretome

Meaning

The Myofiber Secretome represents the complete, dynamic collection of signaling molecules, including various peptides, growth factors, and cytokines, that are actively secreted by skeletal muscle fibers (myofibers) into the interstitial fluid and systemic circulation. This vast collection of molecules, collectively known as myokines, forms the basis of muscle’s profound endocrine function, enabling it to communicate and coordinate activity with distant organs like the liver, adipose tissue, and the brain. The composition of the secretome is dynamically modulated by exercise and nutritional status, serving as a potent systemic modulator of metabolism, immunity, and cellular longevity.