The biological process of enhancing the formation, thickness, or integrity of the myelin sheath, the fatty layer that insulates nerve axons, thereby increasing the speed and efficiency of electrical signal transmission throughout the central and peripheral nervous systems. This improvement is crucial for cognitive and motor function. Optimized myelination directly translates to faster reaction times and clearer thought.
Origin
The term is derived from ‘myelin,’ the substance forming the sheath, and ‘improvement,’ which denotes a clinical goal in neurological health. It stems from neurobiology and developmental science, acknowledging the plasticity of white matter tracts even in adulthood and their responsiveness to biological cues.
Mechanism
Myelination is primarily executed by oligodendrocytes in the central nervous system, and their activity is highly sensitive to the surrounding endocrine environment. Thyroid hormones and sex steroids, particularly progesterone and testosterone metabolites, are known to promote oligodendrocyte differentiation and myelin synthesis. By optimizing these hormonal signals, clinicians can support the structural integrity of neural networks, leading to measurable improvements in processing speed and neurological efficiency.
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