The interdisciplinary field of study and clinical application focused on stimulating and enhancing the body’s intrinsic capacity to repair, rebuild, and maintain skeletal muscle, bone, and connective tissues. In the context of hormonal health, this science is vital because endocrine signals, particularly growth hormone, IGF-1, and sex steroids, are fundamental drivers of tissue anabolism and structural integrity. It fundamentally addresses sarcopenia and osteopenia as systemic hormonal and cellular issues.
Origin
This science is a powerful convergence of orthopedics, sports medicine, cell biology, and endocrinology, formalizing the processes of tissue turnover and repair. The concept of ‘regeneration’ moves beyond simple repair to the active restoration of youthful tissue quality and functional capacity. Hormonal research has long identified the essential, non-negotiable role of the somatotropic and gonadal axes in maintaining robust musculoskeletal health.
Mechanism
The core mechanism involves utilizing mechanical stress through structured exercise, targeted nutrition via specific amino acids, and precise hormonal signaling to activate muscle satellite cells and bone osteoblasts. Growth hormone and IGF-1 directly stimulate protein synthesis and cellular proliferation, while testosterone and estrogen modulate bone remodeling and muscle fiber size. The clinical application is to create an optimal, sustained anabolic environment for continuous, high-quality tissue renewal.
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