The active preservation of the structural soundness and functional capacity of bone, muscle, and connective tissues across the lifespan, which is heavily influenced by the anabolic and anti-catabolic actions of the endocrine system. This is vital for mobility.
Origin
Derived from anatomy and physiology, this term emphasizes the structural requirement (‘integrity’) supported by systemic regulation (‘maintenance’). It is a key focus in longevity science where hormonal support is paramount.
Mechanism
Maintenance relies on adequate signaling from anabolic hormones like testosterone and IGF-1 to promote osteoblast and satellite cell activity, countering catabolic signals such as elevated cortisol or chronic inflammation. Sufficient nutrient delivery, especially protein and specific micronutrients, provides the substrate for this structural preservation.
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