Musculoskeletal healing compounds are a classification of endogenous molecules, therapeutic peptides, and exogenous substances that possess the biological capacity to accelerate the repair and regeneration of bone, cartilage, tendons, and muscle tissue following injury or degenerative stress. These compounds are of clinical interest for enhancing recovery from orthopedic trauma, mitigating age-related decline in tissue integrity, and improving overall physical resilience and structural health. They are vital for maintaining mobility and a high quality of life throughout the lifespan.
Origin
This term is derived from the fields of regenerative medicine and orthopedic biology, combining musculoskeletal, referring to the body’s structural support system, with healing compounds, which denotes substances that facilitate tissue repair and restoration. The concept is based on identifying and leveraging the body’s natural signaling mechanisms for regeneration, often utilizing specific growth factors that are typically more abundant in youth.
Mechanism
The primary mechanism involves modulating the inflammatory phase of healing and stimulating the proliferation and differentiation of local progenitor cells, such as osteoblasts for bone and satellite cells for muscle. Many of these compounds, including specific growth factors and peptides, bind to receptors on local cells, triggering intracellular cascades that promote collagen synthesis, extracellular matrix deposition, and angiogenesis, ultimately rebuilding the damaged tissue architecture.
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