The precise physiological process of increasing skeletal muscle mass and density, resulting from a sustained net positive balance between the rate of muscle protein synthesis and muscle protein breakdown. Clinically, achieving muscular accretion is fundamentally vital for maintaining metabolic health, preserving functional independence, and effectively mitigating sarcopenia, the pathological age-related loss of muscle tissue. It represents the building and strengthening of the body’s essential motor engine.
Origin
A scientific term combining “Muscular” (relating to muscle tissue) and “Accretion” (the process of growth or increase, typically by the gradual accumulation of additional layers or matter). It is a precise term for muscle growth, or hypertrophy, used to emphasize the controlled, systemic nature of the increase.
Mechanism
Heavily reliant on robust anabolic hormonal signaling, primarily driven by adequate levels of testosterone, growth hormone, and insulin-like growth factor 1 (IGF-1), which bind to specific receptors on muscle cells. These critical signals activate the mTOR pathway, leading to a significant increase in protein synthesis and the proliferation of muscle satellite cells. Mechanical tension from consistent resistance exercise and sufficient, timely protein intake are essential co-stimuli for this anabolic response.
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