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Muscle Sympathetic Nerve Activity

Meaning

Muscle Sympathetic Nerve Activity (MSNA) is a direct, quantifiable neurophysiological measure of the efferent neural outflow from the central nervous system specifically directed to the skeletal muscle vasculature. This activity accurately reflects the central sympathetic drive, which is a pivotal component of the autonomic nervous system. MSNA serves as a crucial biomarker for assessing the central regulation of blood pressure, peripheral vascular resistance, and overall cardiovascular risk. Chronic elevation of MSNA is frequently associated with conditions such as essential hypertension, insulin resistance, and stress-related hormonal dysregulation.