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Muscle Protein Synthesis Signaling

Meaning

Muscle Protein Synthesis Signaling refers to the intricate intracellular cascade, primarily involving the PI3K/Akt/mTOR pathway, that governs the rate at which skeletal muscle tissue builds new contractile proteins. This signaling is highly sensitive to mechanical loading, amino acid availability, and anabolic hormones like testosterone and insulin-like growth factor 1 (IGF-1). It is the biochemical command to repair and grow muscle mass.