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Muscle Myokines

Meaning

Muscle Myokines are a diverse group of small signaling peptides and proteins secreted by skeletal muscle fibers, particularly in response to contractile activity or mechanical loading, that exert autocrine, paracrine, or endocrine effects on various distant tissues. These molecules act as crucial chemical messengers, linking muscle activity directly to systemic health outcomes, including metabolism, immunity, and cognitive function. They represent a critical component of the muscle’s recognized role as an active endocrine organ.