Muscle Mass Retention is the physiological imperative to preserve myofibrillar protein structures and overall muscle volume against catabolic breakdown, particularly during periods of caloric deficit, aging, or systemic inflammation. It is the maintenance of functional tissue.
Origin
This is a direct, descriptive term focusing on the maintenance of existing muscle quantity over time, contrasting with the concept of muscle gain. It addresses the negative balance problem in sarcopenia prevention.
Mechanism
This process is largely governed by the anabolic-catabolic balance, demanding robust signaling mediated by Insulin-like Growth Factor 1 (IGF-1) and testosterone to promote muscle protein synthesis. Simultaneously, catabolic signaling pathways, such as those involving myostatin or the ubiquitin-proteasome system, must be effectively suppressed.
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