These are systematic nutritional and physical interventions designed to counteract sarcopenia and maintain skeletal muscle protein balance, especially during periods of caloric deficit or elevated catabolic hormones like cortisol. Preserving lean mass is crucial because muscle tissue is a significant site for glucose disposal and is influenced by anabolic hormones such as testosterone and IGF-1. We aim to maintain functional physiological capacity.
Origin
The protocols are derived from exercise physiology and gerontology, where maintaining muscle integrity is linked to longevity and metabolic health outcomes. The term emphasizes structured, proactive strategies rather than passive maintenance. In wellness science, it connects directly to countering the catabolic effects of chronic stress.
Mechanism
The mechanism relies on providing sufficient high-quality amino acid substrates, particularly leucine, to stimulate the mTOR signaling pathway, which governs muscle protein synthesis. Resistance training provides the necessary mechanical stimulus to upregulate anabolic signaling pathways. Furthermore, optimizing the testosterone-to-cortisol ratio ensures that catabolic signaling is suppressed, allowing net positive protein accretion.
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