Skip to main content

Muscle-Brain Cross-Talk

Meaning

Muscle-Brain Cross-Talk is a bidirectional endocrine and neural communication loop where skeletal muscle actively signals to the central nervous system, influencing cognitive function, metabolism, and mood. This dialogue is primarily mediated by myokines, which are small protein hormones secreted by muscle fibers, along with metabolites released during physical contraction. This physiological axis highlights that muscle is not merely a motor organ but a potent endocrine gland capable of coordinating systemic health and neuroplasticity.