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Muscle-Brain Connection

Meaning

The Muscle-Brain Connection, also referred to as the myokine-mediated neuro-muscular axis, describes the bidirectional communication pathway between skeletal muscle tissue and the central nervous system. This vital physiological link is mediated by a complex array of signaling molecules, including myokines released by muscle during contraction, which cross the blood-brain barrier to influence cognitive function, mood, and neurogenesis. Preserving muscle mass and function is therefore a neuroprotective strategy, as muscle acts as an endocrine organ that directly supports brain health and resilience.