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Muscle Atrophy

Meaning

Muscle atrophy is the clinical term for the progressive wasting, thinning, and decrease in the mass and strength of skeletal muscle tissue, resulting from a reduction in the size of individual muscle fibers. This condition is a significant concern in longevity and hormonal health, as it is often accelerated by age-related sarcopenia, disuse, chronic illness, or endocrine disorders like Cushing’s syndrome or severe hypogonadism. Atrophy compromises physical function, metabolic health, and overall quality of life, increasing the risk of falls and frailty.