Muscle Anabolic Efficiency describes the quantitative rate at which available precursors, such as amino acids, are converted into new contractile protein within skeletal muscle tissue under the influence of anabolic signals. High efficiency signifies minimal waste in the protein synthesis pathway. We measure how effectively the body builds muscle.
Origin
This metric is derived from exercise biochemistry and nitrogen balance studies, focusing on the kinetics of muscle protein accretion post-stimulus. It moves beyond simple mass gain to assess the underlying biological effectiveness.
Mechanism
Efficiency is mechanistically determined by the magnitude and duration of anabolic signaling, primarily through the activation of the mTOR pathway following resistance exercise or nutrient ingestion. Adequate upstream signaling from insulin, IGF-1, and testosterone is required to maximize the rate of translation initiation and elongation at the ribosome.
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