What is the Origin of MuRF1 Atrogin-1 Suppression?

This term is strictly from molecular biology and muscle physiology, directly referencing the specific gene products involved in the ubiquitin-proteasome pathway of muscle breakdown. The concept emerged from research into the cellular mechanisms of muscle wasting.

What is the Mechanism of MuRF1 Atrogin-1 Suppression?

The mechanism of suppression typically involves activating anabolic signaling pathways, such as the Akt/mTOR pathway, which can transcriptionally repress the expression of MuRF1 and Atrogin-1. Hormones like testosterone and insulin-like growth factor 1 (IGF-1) are potent suppressors, promoting protein synthesis over degradation. By downregulating these key ligases, the rate of muscle protein ubiquitination decreases, effectively halting the major pathway of muscle wasting.

MuRF1 Atrogin-1 Suppression ∞ Area

MuRF1 Atrogin-1 Suppression

Meaning

MuRF1 Atrogin-1 Suppression is the molecular objective of inhibiting the activity or expression of two specific ubiquitin ligase enzymes, Muscle RING-finger protein-1 (MuRF1) and Atrogin-1 (also known as MAFbx). These enzymes are known as atrogenes because they are central mediators of muscle protein degradation and atrophy, particularly in catabolic states induced by disease or hormonal deficiency. Achieving their suppression is a therapeutic strategy for preserving lean muscle mass and combating sarcopenia.