Skip to main content

mTOR Signaling Cycles

Meaning

mTOR Signaling Cycles describe the rhythmic, nutrient- and energy-sensitive activation and deactivation of the mechanistic Target of Rapamycin (mTOR) pathway, a central regulator of cell growth, proliferation, and metabolism. Optimizing these cycles involves strategically balancing periods of mTOR activation, which promotes anabolism and muscle protein synthesis, with periods of mTOR inhibition, which stimulates cellular cleanup via autophagy and supports longevity pathways. This cycling is a critical component of metabolic health and anti-aging protocols.