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MTNR1B Variant

Meaning

The MTNR1B Variant refers to specific single nucleotide polymorphisms (SNPs) within the gene encoding the Melatonin Receptor Type 1B, a G-protein coupled receptor that mediates the actions of the hormone melatonin in regulating circadian rhythms and glucose metabolism. Certain common variants, particularly a specific risk allele, are clinically associated with impaired pancreatic beta-cell function, reduced insulin secretion capacity, and an increased risk for developing type 2 diabetes. This genetic variation represents a crucial link between chronobiology and metabolic endocrinology.