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MRGPRX2

Meaning

Mas-related G protein-coupled receptor member X2 (MRGPRX2) is a specialized receptor primarily expressed on the surface of mast cells, a type of immune cell crucial for allergic responses. This receptor is significant because it mediates non-IgE-dependent mast cell activation, meaning it can trigger the release of inflammatory mediators, like histamine, without the involvement of a true allergic antibody. MRGPRX2 is a key target in understanding and managing pseudo-allergic reactions and drug hypersensitivity.