What is the Origin of MOTS-c Metabolism?

The peptide MOTS-c was relatively recently discovered, originating from the mitochondrial genome, a unique feature distinguishing it from peptides encoded by the nuclear genome. Its name reflects its origin and structure. The study of its metabolic role is a cutting-edge area of mitochondrial medicine.

What is the Mechanism of MOTS-c Metabolism?

MOTS-c functions by translocating to the nucleus, where it influences the transcription of genes related to metabolism. It promotes glucose uptake in muscle cells independent of the canonical insulin signaling pathway, thereby improving systemic insulin sensitivity. This mechanism links mitochondrial health directly to whole-body energy balance and provides a novel perspective on metabolic control beyond traditional hormonal axes.

MOTS-c Metabolism

Meaning

MOTS-c Metabolism refers to the physiological actions and regulatory pathways associated with the mitochondrial-derived peptide MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c). This peptide is recognized as a significant regulator of metabolic homeostasis, primarily by influencing insulin sensitivity and glucose utilization in skeletal muscle. Clinically, understanding its metabolism provides insight into cellular energy regulation and potential targets for addressing metabolic dysfunction.