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MOTS-c Metabolic Regulation

Meaning

MOTS-c metabolic regulation refers to the critical control exerted by the mitochondrial-derived peptide MOTS-c over systemic metabolic homeostasis and energy utilization. This short peptide, encoded in the mitochondrial genome, acts as a crucial signal that communicates the metabolic status of the mitochondria to the rest of the cell and body, effectively functioning as a mitochondrial hormone. Its function is essential for maintaining insulin sensitivity, regulating whole-body glucose metabolism, and promoting cellular energy efficiency, particularly in skeletal muscle.