What is the Origin of MOTS-c Metabolic Function?

MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c) was discovered relatively recently, originating from the mitochondrial genome, which is unusual for regulatory peptides. The term is rooted in molecular biology and endocrinology, specifically linking mitochondrial activity to whole-body metabolism. Its clinical interest stems from its potential as a novel therapeutic target for conditions like insulin resistance.

What is the Mechanism of MOTS-c Metabolic Function?

The mechanism of action is predominantly localized in skeletal muscle, where MOTS-c is thought to translocate to the nucleus and influence the transcription of genes related to metabolic pathways. Specifically, it improves insulin sensitivity by enhancing glucose uptake into muscle cells and promoting the efficiency of the body's energy-producing processes. This action helps maintain systemic glucose balance, directly supporting healthy aging and energetic vitality.

MOTS-c Metabolic Function ∞ Area

MOTS-c Metabolic Function

Meaning

MOTS-c Metabolic Function refers to the biological role of the mitochondrial-derived peptide MOTS-c in regulating systemic metabolic homeostasis, primarily by influencing glucose metabolism and insulin sensitivity. This peptide acts as a signal to the body, particularly skeletal muscle, enhancing its ability to utilize glucose and promoting cellular energy balance. Optimized MOTS-c function is a critical component of metabolic health and may mitigate age-related metabolic dysfunction.