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MOTS-C Activation

Meaning

MOTS-C Activation is the physiological or pharmacological process of stimulating the biological activity of the Mitochondrial Open Reading Frame of the 12S rRNA Type-c (MOTS-c) peptide, a mitochondrial-derived signaling molecule. This activation is clinically relevant because MOTS-c acts as an “exercise mimetic,” primarily promoting insulin sensitivity and metabolic homeostasis throughout the body. Increased MOTS-c activity is associated with improved glucose utilization and enhanced cellular resilience against metabolic stress.