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MOTS-c

Meaning

MOTS-c, or Mitochondrial Open Reading Frame of the 12S rRNA Type-c, is a recently discovered small peptide encoded within the mitochondrial genome that functions as a potent mitochondrial-derived hormone. It plays a significant regulatory role in metabolic homeostasis, particularly within skeletal muscle tissue, where it enhances insulin sensitivity and promotes systemic glucose metabolism. Functionally, MOTS-c is recognized as a key mediator in the essential communication between the mitochondria and the rest of the cell, profoundly impacting longevity and overall metabolic health.