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Motivation Substrate

Meaning

The Motivation Substrate is the underlying neurochemical and hormonal foundation that governs an individual’s drive, initiative, and capacity for sustained effort. This substrate is fundamentally regulated by the interplay of key neuroendocrine factors, primarily the catecholamines like dopamine and norepinephrine, and their interaction with thyroid and adrenal hormones. Optimizing this substrate is a clinical objective for enhancing cognitive performance, focus, and overall engagement with life.