The specific configuration of circulating neurochemicals, including serotonin, GABA, dopamine, and the appropriate balance of steroid hormones, that results in emotional equilibrium and resilience against affective volatility. This state minimizes pathological swings in mood, anxiety, and irritability often associated with endocrine dysregulation. It is the biochemical substrate for emotional consistency.
Origin
Originating from psychopharmacology and endocrinology, this term describes the desired chemical milieu that promotes affective neutrality and stability. ‘Chemistry’ points directly to the molecular underpinnings rather than purely psychological interventions.
Mechanism
Stabilization is achieved when neurotransmitter turnover rates are appropriate and receptor sensitivity is maintained across key limbic structures. Optimal allopregnanolone levels, for instance, can enhance GABAergic inhibitory tone, reducing neuronal excitability and thereby mitigating anxiety spikes. Additionally, consistent testosterone or estrogen signaling supports dopaminergic pathways linked to motivation and emotional regulation.
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