Skip to main content

Monofollicular Development

Meaning

Monofollicular development describes the physiological process in a typical ovarian cycle where a single dominant ovarian follicle is selected from a cohort of developing follicles to reach full maturity and undergo ovulation. This tightly regulated selection process ensures the release of only one oocyte, preventing multiple pregnancies under natural conditions. In clinical reproductive endocrinology, particularly during ovarian stimulation for fertility treatments, the goal is often to achieve controlled monofollicular development to optimize the chance of a single, healthy pregnancy. The process relies on precise hormonal signaling and follicular responsiveness.